Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routine care

BACKGROUND: Hotspot mutations of the oncogenes BRAF and NRAS are the most common genetic alterations in cutaneous melanoma. Specific inhibitors of BRAF and MEK have shown significant survival benefits in large phase III trials. However, the prognostic significance of BRAF and NRAS mutations outside...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:BMC Cancer
Prif Awduron: Heppt, Markus V., Siepmann, Timo, Engel, Jutta, Schubert-Fritschle, Gabriele, Eckel, Renate, Mirlach, Laura, Kirchner, Thomas, Jung, Andreas, Gesierich, Anja, Ruzicka, Thomas, Flaig, Michael J., Berking, Carola
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553744/
https://ncbi.nlm.nih.gov/pubmed/28797232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3529-5
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