A phased SNP-based classification of sickle cell anemia HBB haplotypes

BACKGROUND: Sickle cell anemia causes severe complications and premature death. Five common β-globin gene cluster haplotypes are each associated with characteristic fetal hemoglobin (HbF) levels. As HbF is the major modulator of disease severity, classifying patients according to haplotype is useful...

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Detalhes bibliográficos
Publicado no:BMC Genomics
Main Authors: Shaikho, Elmutaz M., Farrell, John J., Alsultan, Abdulrahman, Qutub, Hatem, Al-Ali, Amein K., Figueiredo, Maria Stella, Chui, David H.K., Farrer, Lindsay A., Murphy, George J., Mostoslavsky, Gustavo, Sebastiani, Paola, Steinberg, Martin H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553663/
https://ncbi.nlm.nih.gov/pubmed/28800727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-4013-y
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