Deletion mutagenesis using an 'M13 splint': the N-terminal structural domain of tyrosyl-tRNA synthetase (B. stearothermophilus) catalyses the formation of tyrosyl adenylate.

The X-ray crystallographic structure of tyrosyl-tRNA synthetase (TyrTS) comprises only the N-terminal 320 amino acids of the molecule as the C-terminal 99 amino acids are poorly ordered in the crystal. A new technique, employing a single-stranded M13 splint, has been used to direct a deletion in the...

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Detalles Bibliográficos
Publicado en:EMBO J
Autores principales: Waye, M M, Winter, G, Wilkinson, A J, Fersht, A R
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1983
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC555366/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6315404/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1983.tb01665.x
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