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Pharmacokinetics and drug-interactions determine optimum combination strategies in computational models of cancer evolution

The identification of optimal drug administration schedules to battle the emergence of resistance is a major challenge in cancer research. The existence of a multitude of resistance mechanisms necessitates administering drugs in combination, significantly complicating the endeavor of predicting the...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Chakrabarti, Shaon, Michor, Franziska
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553595/
https://ncbi.nlm.nih.gov/pubmed/28566331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2871
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