Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

High-grade pancreatic intraepithelial neoplasia (HG-PanIN) is the major precursor of pancreatic ductal adenocarcinoma (PDAC) and is an ideal target for early detection. To characterize pure HG-PanIN, we analysed 23 isolated HG-PanIN lesions occurring in the absence of PDAC. Whole-exome sequencing of...

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Publié dans:J Pathol
Auteurs principaux: Hosoda, Waki, Chianchiano, Peter, Griffin, James F, Pittman, Meredith E, Brosens, Lodewijk AA, Noë, Michaël, Yu, Jun, Shindo, Koji, Suenaga, Masaya, Rezaee, Neda, Yonescu, Raluca, Ning, Yi, Albores-Saavedra, Jorge, Yoshizawa, Naohiko, Harada, Kenichi, Yoshizawa, Akihiko, Hanada, Keiji, Yonehara, Shuji, Shimizu, Michio, Uehara, Takeshi, Samra, Jaswinder S, Gill, Anthony J, Wolfgang, Christopher L, Goggins, Michael G, Hruban, Ralph H, Wood, Laura D
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553451/
https://ncbi.nlm.nih.gov/pubmed/28188630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4884
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