Inhibition of CDK-mediated Smad3 phosphorylation reduces the Pin1-Smad3 interaction and aggressiveness of triple negative breast cancer cells

Triple negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that lacks effective targeted therapies. Although TNBC is not defined by specific therapeutic targets, a subset of patients have tumors that overexpress cyclins. High cyclin D/E expression catalyzes CDK4/2 activity. In...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Thomas, Alexandra L., Lind, Hanne, Hong, Angela, Dokic, Danijela, Oppat, Kailey, Rosenthal, Elana, Guo, Amina, Thomas, Aaron, Hamden, Randala, Jeruss, Jacqueline S.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553400/
https://ncbi.nlm.nih.gov/pubmed/28678584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1338988
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