The upregulation of integrin α(D)β(2) (CD11d/CD18) on inflammatory macrophages promotes macrophage retention in vascular lesions and development of atherosclerosis

Macrophage accumulation is a critical step during development of chronic inflammation, initiating progression of many devastating diseases. Leukocyte-specific integrin α(D)β(2) (CD11d/CD18) is dramatically upregulated on macrophages at inflammatory sites. Previously we found that CD11d overexpressio...

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Udgivet i:J Immunol
Main Authors: Aziz, Moammir, Cui, Kui, Das, Mitali, Brown, Kathleen E., Ardell, Christopher L., Febbraio, Maria, Pluskota, Elzbieta, Han, Juying, Wu, Huaizhu, Ballantyne, Christie M., Smith, Jonathan D., Cathcart, Martha K., Yakubenko, Valentin P.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553324/
https://ncbi.nlm.nih.gov/pubmed/28500072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1602175
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