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Monte Carlo simulations of randomized clinical trials in epilepsy

BACKGROUND: The placebo response in epilepsy randomized clinical trials (RCTs) has recently been shown to largely reflect underlying natural variability in seizure frequency. Based on this observation, we sought to explore the parameter space of RCT design to optimize trial efficiency and cost. METH...

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: Goldenholz, Daniel M., Tharayil, Joseph, Moss, Robert, Myers, Evan, Theodore, William H.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553226/
https://ncbi.nlm.nih.gov/pubmed/28812044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.426
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