Deglycosylation altered the gating properties of rNav1.3: glycosylation/deglycosylation homeostasis probably complicates the functional regulation of voltage-gated sodium channel

OBJECTIVE: To examine the effect of deglycosylation on gating properties of rNav1.3. METHODS: rNav1.3 was expressed in Xenopus oocyte, with glycosylation inhibition by using tunicamycin. Two-electrode voltage clamp was employed to record the whole-cell sodium current and data were analyzed by Origin...

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Опубликовано в: :Neurosci Bull
Главные авторы: Xu, Qing, Cheng, Hui-Wen, He, Hui-Qiong, Liu, Zhi-Rui, He, Ming, Yang, Hong-Tian, Zhou, Zhi-Lei, Ji, Yong-Hua
Формат: Artigo
Язык:Inglês
Опубликовано: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2008
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552531/
https://ncbi.nlm.nih.gov/pubmed/18839021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-008-0524-5
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