Thrombin-induced microglial activation contributes to the degeneration of nigral dopaminergic neurons in vivo

OBJECTIVE: To evaluate the role of thrombin-activated microglia in the neurodegeneration of nigral dopaminergic neurons in the rat substantia nigra (SN) in vivo. METHODS: After stereotaxic thrombin injection into unilateral SN of rats, immunostaining, reverse transcription polymerase chain reaction...

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Detalles Bibliográficos
Publicado en:Neurosci Bull
Main Authors: Huang, Cheng-Fang, Li, Gang, Ma, Rong, Sun, Sheng-Gang, Chen, Jian-Guo
Formato: Artigo
Idioma:Inglês
Publicado: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2008
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552513/
https://ncbi.nlm.nih.gov/pubmed/18369384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-008-0066-x
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