Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging

Methotrexate (MTX) is an immunosuppressant commonly used for the treatment of autoimmune diseases. Recent observations have shown that patients treated with MTX also exhibit a reduced risk for the development of cardiovascular disease (CVD). Although MTX reduces systemic inflammation and tissue dama...

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Bibliographic Details
Published in:Redox Biol
Main Authors: Zimmerman, Matthew C., Clemens, Dahn L., Duryee, Michael J., Sarmiento, Cleofes, Chiou, Andrew, Hunter, Carlos D., Tian, Jun, Klassen, Lynell W., O’Dell, James R., Thiele, Geoffrey M., Mikuls, Ted R., Anderson, Daniel R.
Format: Artigo
Language:Inglês
Published: Elsevier 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552384/
https://ncbi.nlm.nih.gov/pubmed/28803127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.07.018
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