Immunogenic and Inflammatory Responses to Citrullinated Proteins Are Enhanced Following Modification with Malondialdehyde-Acetaldehyde Adducts

BACKGROUND/OBJECTIVE: Malondialdehyde-acetaldehyde adducts (MAA) act as potent immune adjuvants and co-localize with citrullinated antigens in tissues effected by rheumatoid arthritis (RA). We sought to examine the role of MAA-adducts in promoting RA-related autoimmunity and inflammation. METHODS: D...

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Publicat a:Int Immunopharmacol
Autors principals: Thiele, Geoffrey M., Duryee, Michael J., Hunter, Carlos D., England, Bryant R., Fletcher, Benjamin S., Daubach, Eric C., Pospisil, Taylor P., Klassen, Lynell W., Mikuls, Ted R.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250734/
https://ncbi.nlm.nih.gov/pubmed/32224441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.intimp.2020.106433
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