Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

In order to inform the rational design of HIV-1 preventive and cure interventions it is critical to understand the events occurring during acute HIV-1 infection (AHI). Using viral deep sequencing on six participants from the early capture acute infection RV217 cohort, we have studied HIV-1 evolution...

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Pubblicato in:PLoS Pathog
Autori principali: Kijak, Gustavo H., Sanders-Buell, Eric, Chenine, Agnes-Laurence, Eller, Michael A., Goonetilleke, Nilu, Thomas, Rasmi, Leviyang, Sivan, Harbolick, Elizabeth A., Bose, Meera, Pham, Phuc, Oropeza, Celina, Poltavee, Kultida, O’Sullivan, Anne Marie, Billings, Erik, Merbah, Melanie, Costanzo, Margaret C., Warren, Joanna A., Slike, Bonnie, Li, Hui, Peachman, Kristina K., Fischer, Will, Gao, Feng, Cicala, Claudia, Arthos, James, Eller, Leigh A., O’Connell, Robert J., Sinei, Samuel, Maganga, Lucas, Kibuuka, Hannah, Nitayaphan, Sorachai, Rao, Mangala, Marovich, Mary A., Krebs, Shelly J., Rolland, Morgane, Korber, Bette T., Shaw, George M., Michael, Nelson L., Robb, Merlin L., Tovanabutra, Sodsai, Kim, Jerome H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552316/
https://ncbi.nlm.nih.gov/pubmed/28759651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006510
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