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Toxicological and bio-distribution profile of a GM-CSF-expressing, double-targeted, chimeric oncolytic adenovirus ONCOS-102 – Support for clinical studies on advanced cancer treatment

The purpose of this work was to carry out preclinical toxicity and bio-distribution studies required for regulatory approval of a clinical trial application for Phase I clinical studies of ONCOS-102 (Ad5/3-D24-GM-CSF) for therapy of advanced cancers (NCT01598129). The study design, route of administ...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Kuryk, Lukasz, Vassilev, Lotta, Ranki, Tuuli, Hemminki, Akseli, Karioja-Kallio, Aila, Levälampi, Onerva, Vuolanto, Antti, Cerullo, Vincenzo, Pesonen, Sari
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552138/
https://ncbi.nlm.nih.gov/pubmed/28796812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182715
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