The quinic acid derivative KZ-41 prevents glucose-induced caspase-3 activation in retinal endothelial cells through an IGF-1 receptor dependent mechanism

Retinal microaneurysms, an early disease manifestation of diabetic retinopathy, are associated with retinal endothelial cell (REC) death and macular edema. We previously demonstrated that a quinic acid (QA) analog, KZ-41, promoted REC survival by blunting stress-induced p38 MAPK activation. Herein,...

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發表在:PLoS One
Main Authors: He, Hui, Weir, Rebecca L., Toutounchian, Jordan J., Pagadala, Jayaprakash, Steinle, Jena J., Baudry, Jerome, Miller, Duane D., Yates, Charles R.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552119/
https://ncbi.nlm.nih.gov/pubmed/28796787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180808
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