Alterations in Epidermal Eicosanoid Metabolism Contribute to Inflammation and Impaired Late Differentiation in FLG-Mutated Atopic Dermatitis

Loss-of-function mutations in the FLG gene cause ichthyosis vulgaris (IV) and represent the major predisposing genetic risk factor for atopic dermatitis (AD). Although both conditions are characterized by epidermal barrier impairment, AD also exhibits signs of inflammation. This work was aimed at de...

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Gepubliceerd in:J Invest Dermatol
Hoofdauteurs: Blunder, Stefan, Rühl, Ralph, Moosbrugger-Martinz, Verena, Krimmel, Christine, Geisler, Anita, Zhu, Huiting, Crumrine, Debra, Elias, Peter M., Gruber, Robert, Schmuth, Matthias, Dubrac, Sandrine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551680/
https://ncbi.nlm.nih.gov/pubmed/27793761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.09.034
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