Alterations in Epidermal Eicosanoid Metabolism Contribute to Inflammation and Impaired Late Differentiation in FLG-Mutated Atopic Dermatitis

Loss-of-function mutations in the FLG gene cause ichthyosis vulgaris (IV) and represent the major predisposing genetic risk factor for atopic dermatitis (AD). Although both conditions are characterized by epidermal barrier impairment, AD also exhibits signs of inflammation. This work was aimed at de...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Main Authors: Blunder, Stefan, Rühl, Ralph, Moosbrugger-Martinz, Verena, Krimmel, Christine, Geisler, Anita, Zhu, Huiting, Crumrine, Debra, Elias, Peter M., Gruber, Robert, Schmuth, Matthias, Dubrac, Sandrine
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551680/
https://ncbi.nlm.nih.gov/pubmed/27793761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.09.034
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