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Tudor-SN-mediated endonucleolytic decay of human-cell microRNAs promotes G1/S phase transition
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Compared to miRNA biogenesis, pathways that mediate mature miRNA decay are less-well understood. We report that biologically functional miRNAs are degraded in human cells by the endonuclease Tudor-SN (TSN). In vitro, recombi...
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| Publicado no: | Science |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5551500/ https://ncbi.nlm.nih.gov/pubmed/28546213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aai9372 |
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