Pharmacokinetics and Pharmacodynamics Evaluation of Tramadol in Thermoreversible Gels

We evaluated pharmacokinetics (PK) and pharmacodynamics (PD) induced by new formulations of tramadol (TR) in thermoreversible gels. The poloxamer- (PL-) tramadol systems were prepared by direct dispersion of the drug in solutions with PL 407 and PL 188. The evaluated formulations were as follows: F1...

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Vydáno v:Biomed Res Int
Hlavní autoři: Papini, Juliana Zampoli Boava, Cereda, Cíntia Maria Saia, Pedrazzoli Júnior, José, Calafatti, Silvana Aparecida, de Araújo, Daniele Ribeiro, Tofoli, Giovana Radomille
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551468/
https://ncbi.nlm.nih.gov/pubmed/28819627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5954629
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