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Thermoreversible Nasal In situ Gel of Venlafaxine Hydrochloride: Formulation, Characterization, and Pharmacodynamic Evaluation

In order to improve the bioavailability of the antidepressant drug, venlafaxine hydrochloride, in situ mucoadhesive thermoreversible gel, was formulated using Lutrol F127 (18%) as a thermo gelling polymer. Mucoadhesion was modulated by trying carbopol 934, PVP K30, HPMC K4M, sodium alginate, tamarin...

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Detalhes bibliográficos
Main Authors: Bhandwalkar, Mandar J., Avachat, Amelia M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581675/
https://ncbi.nlm.nih.gov/pubmed/23229381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-012-9893-1
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