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Local sequence and sequencing depth dependent accuracy of RNA-seq reads

BACKGROUND: Many biases and spurious effects are inherent in RNA-seq technology, resulting in a non-uniform distribution of sequencing read counts for each base position in a gene. Therefore, a base-level strategy is required to model the non-uniformity. Also, the properties of sequencing read count...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Cai, Guoshuai, Liang, Shoudan, Zheng, Xiaofeng, Xiao, Feifei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550947/
https://ncbi.nlm.nih.gov/pubmed/28793860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-017-1780-z
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