T-cell autonomous death induced by regeneration of inert glucocorticoid metabolites

Glucocorticoids (GC) are essential regulators of T-cell development and function. Activation of the immune system increases systemic adrenal-derived GC levels which downregulate immune activity as part of a negative feedback control system. Increasing evidence shows, however, that GC can also be der...

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Опубликовано в: :Cell Death Dis
Главные авторы: Rocamora-Reverte, Lourdes, Reichardt, Holger M, Villunger, Andreas, Wiegers, GJan
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550885/
https://ncbi.nlm.nih.gov/pubmed/28726773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.344
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