Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells

Sorcin is a calcium binding protein that plays an important role in multidrug resistance (MDR) in tumors, since its expression confers resistance to doxorubicin and to other chemotherapeutic drugs. In this study, we show that Sorcin is able to bind doxorubicin, vincristine, paclitaxel and cisplatin...

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Dades bibliogràfiques
Publicat a:Cell Death Dis
Autors principals: Genovese, Ilaria, Fiorillo, Annarita, Ilari, Andrea, Masciarelli, Silvia, Fazi, Francesco, Colotti, Gianni
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550883/
https://ncbi.nlm.nih.gov/pubmed/28726784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.342
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