mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation

mTORC2 is aberrantly activated in cancer and therefore is considered to be an important therapeutic target. The hedgehog pathway, which is also often hyperactivated, regulates transcription of several genes associated with angiogenesis, metastasis, cellular proliferation and cancer stem cell (CSC) r...

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Vydáno v:Cell Death Dis
Hlavní autoři: Maiti, Samarpan, Mondal, Susmita, Satyavarapu, Eswara M, Mandal, Chitra
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550848/
https://ncbi.nlm.nih.gov/pubmed/28703798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.296
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