Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME

AIM: To counteract/reveal celecoxib-induced toxicity and NO system involvement. METHODS: Celecoxib (1 g/kg b.w. ip) was combined with therapy with stable gastric pentadecapeptide BPC 157 (known to inhibit these lesions, 10 μg/kg, 10 ng/kg, or 1 ng/kg ip) and L-arginine (100 mg/kg ip), as well as NOS...

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Vydáno v:World J Gastroenterol
Hlavní autoři: Drmic, Domagoj, Kolenc, Danijela, Ilic, Spomenko, Bauk, Lara, Sever, Marko, Zenko Sever, Anita, Luetic, Kresimir, Suran, Jelena, Seiwerth, Sven, Sikiric, Predrag
Médium: Artigo
Jazyk:Inglês
Vydáno: Baishideng Publishing Group Inc 2017
Témata:
Basic Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550779/
https://ncbi.nlm.nih.gov/pubmed/28839430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v23.i29.5304
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