Pathogenicity Locus, Core Genome, and Accessory Gene Contributions to Clostridium difficile Virulence

Clostridium difficile is a spore-forming anaerobic bacterium that causes colitis in patients with disrupted colonic microbiota. While some individuals are asymptomatic C. difficile carriers, symptomatic disease ranges from mild diarrhea to potentially lethal toxic megacolon. The wide disease spectru...

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Bibliographic Details
Published in:mBio
Main Authors: Lewis, Brittany B., Carter, Rebecca A., Ling, Lilan, Leiner, Ingrid, Taur, Ying, Kamboj, Mini, Dubberke, Erik R., Xavier, Joao, Pamer, Eric G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550754/
https://ncbi.nlm.nih.gov/pubmed/28790208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00885-17
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