A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies

Single nucleotide variants (SNVs) identified in cancer genomes can be de-convolved using non-negative matrix factorization (NMF) into discrete trinucleotide-based mutational signatures indicative of specific cancer-causing processes. The stability of NMF-generated mutational signatures depends upon...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Davidson, Philip R., Sherborne, Amy L., Taylor, Barry, Nakamura, Alice O., Nakamura, Jean L.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550450/
https://ncbi.nlm.nih.gov/pubmed/28794481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07888-0
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