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A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies
Single nucleotide variants (SNVs) identified in cancer genomes can be de-convolved using non-negative matrix factorization (NMF) into discrete trinucleotide-based mutational signatures indicative of specific cancer-causing processes. The stability of NMF-generated mutational signatures depends upon...
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Publicado no: | Sci Rep |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group UK
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5550450/ https://ncbi.nlm.nih.gov/pubmed/28794481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07888-0 |
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