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Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis
The mechanism for Myc-induced genetic instability is not well understood. Here we show that sublethal activation of Caspase-3 plays an essential, facilitative role in Myc-induced genomic instability and oncogenic transformation. Overexpression of Myc resulted in increased numbers of chromosome aberr...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5550274/ https://ncbi.nlm.nih.gov/pubmed/28691902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26371 |
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