The RhoJ-BAD signaling network: An Achilles’ heel for BRAF mutant melanomas

Genes and pathways that allow cells to cope with oncogene-induced stress represent selective cancer therapeutic targets that remain largely undiscovered. In this study, we identify a RhoJ signaling pathway that is a selective therapeutic target for BRAF mutant cells. RhoJ deletion in BRAF mutant mel...

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Pubblicato in:PLoS Genet
Autori principali: Ruiz, Rolando, Jahid, Sohail, Harris, Melissa, Marzese, Diego M., Espitia, Francisco, Vasudeva, Priya, Chen, Chi-Fen, de Feraudy, Sebastien, Wu, Jie, Gillen, Daniel L., Krasieva, Tatiana B., Tromberg, Bruce J., Pavan, William J., Hoon, Dave S., Ganesan, Anand K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549996/
https://ncbi.nlm.nih.gov/pubmed/28753606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006913
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