Mitochondrial oxidative stress is the achille's heel of melanoma cells resistant to Braf-mutant inhibitor

Vemurafenib/PLX4032, a selective inhibitor of mutant BRAFV600E, constitutes a paradigm shift in melanoma therapy. Unfortunately, acquired resistance, which unavoidably occurs, represents one major limitation to clinical responses. Recent studies have highlighted that vemurafenib activated oxidative...

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Détails bibliographiques
Auteurs principaux: Corazao-Rozas, Paola, Guerreschi, Pierre, Jendoubi, Manel, André, Fanny, Jonneaux, Aurélie, Scalbert, Camille, Garçon, Guillaume, Malet-Martino, Myriam, Balayssac, Stéphane, Rocchi, Stephane, Savina, Ariel, Formstecher, Pierre, Mortier, Laurent, Kluza, Jérome, Marchetti, Philippe
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2013
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875764/
https://ncbi.nlm.nih.gov/pubmed/24161908
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