Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK

As a major diarrheagenic human pathogen, enterohemorrhagic Escherichia coli (EHEC) produce attaching and effacing (A/E) lesions, characterized by the formation of actin pedestals, on mammalian cells. A bacterial T3SS effector NleL from EHEC O157:H7 was recently shown to be a HECT-like E3 ligase in v...

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Detalles Bibliográficos
Publicado en:PLoS Pathog
Main Authors: Sheng, Xiangpeng, You, Qing, Zhu, Hongnian, Chang, ZeNan, Li, Qingrun, Wang, Haifeng, Wang, Chen, Wang, Hongyan, Hui, Lijian, Du, Chongtao, Xie, Xiaoduo, Zeng, Rong, Lin, Anning, Shi, Dongfang, Ruan, Kangcheng, Yan, Jinghua, Gao, George Fu, Shao, Feng, Hu, Ronggui
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549993/
https://ncbi.nlm.nih.gov/pubmed/28753655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006534
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