Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development

OBJECTIVE: The upregulated expression of heparin binding EGF-like growth factor (HB-EGF) in the vessel and circulation is associated with risk of cardiovascular disease. In this study, we tested the effects of HB-EGF targeting using HB-EGF-specific antisense oligonucleotide (ASO) on the development...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kim, Seonwook, Yang, Lihua, Kim, Seongu, Lee, Richard G., Graham, Mark J., Berliner, Judith A., Lusis, Aldons J., Cai, Lei, Temel, Ryan E., Rateri, Debra L., Lee, Sangderk
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549937/
https://ncbi.nlm.nih.gov/pubmed/28792970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182566
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