Upregulation of an inward rectifying K(+) channel can rescue slow Ca(2+) oscillations in K(ATP) channel deficient pancreatic islets

Plasma insulin oscillations are known to have physiological importance in the regulation of blood glucose. In insulin-secreting β-cells of pancreatic islets, K(ATP) channels play a key role in regulating glucose-dependent insulin secretion. In addition, they convey oscillations in cellular metabolis...

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Udgivet i:PLoS Comput Biol
Main Authors: Yildirim, Vehpi, Vadrevu, Suryakiran, Thompson, Benjamin, Satin, Leslie S., Bertram, Richard
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549769/
https://ncbi.nlm.nih.gov/pubmed/28749940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005686
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