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Multivalent interactions by the Set8 histone methyltransferase with its nucleosome substrate
Set8 is the only mammalian monomethyltransferase responsible for H4K20me1, a methyl mark critical for genomic integrity of eukaryotic cells. We present here a structural model for how Set8 uses multivalent interactions to bind and methylate the nucleosome based on crystallographic and solution studi...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5549631/ https://ncbi.nlm.nih.gov/pubmed/26953260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.02.025 |
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