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A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T Cell Receptor and SLP-76 Complex

Phospholipase C gamma 1 (PLC-γ1) occupies a critically important position in the T cell signaling pathway. While its functions as a regulator of both Ca(2+) signaling and PKC-family kinases are well characterized, PLC-γ1’s role in the regulation of early T cell receptor signaling events is incomplet...

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Detalhes bibliográficos
Publicado no:J Proteome Res
Principais autores: Belmont, Judson, Gu, Tao, Mudd, Ashley, Salomon, Arthur R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549626/
https://ncbi.nlm.nih.gov/pubmed/28644030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.6b01026
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