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Performance of objective functions and optimisation procedures for parameter estimation in system biology models

Mathematical modelling of signalling pathways aids experimental investigation in system and synthetic biology. Ever increasing data availability prompts the development of large dynamic models with numerous parameters. In this paper, we investigate how the number of unknown parameters affects the co...

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Bibliografiske detaljer
Udgivet i:NPJ Syst Biol Appl
Main Authors: Degasperi, Andrea, Fey, Dirk, Kholodenko, Boris N.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548920/
https://ncbi.nlm.nih.gov/pubmed/28804640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-017-0023-2
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