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Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells

The in vitro expansion of long-term hematopoietic stem cells (HSCs) remains a substantial challenge, largely because of our limited understanding of the mechanisms that control HSC fate choices. Using single-cell multigene expression analysis and time-lapse microscopy, here we define gene expression...

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Detalles Bibliográficos
Publicado en:Nat Commun
Main Authors: Roch, Aline, Giger, Sonja, Girotra, Mukul, Campos, Vasco, Vannini, Nicola, Naveiras, Olaia, Gobaa, Samy, Lutolf, Matthias P.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548907/
https://ncbi.nlm.nih.gov/pubmed/28790449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00291-3
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