Mechanism of transfer of NO from extracellular S-nitrosothiols into the cytosol by cell-surface protein disulfide isomerase

N-dansylhomocysteine (DnsHCys) is quenched on S-nitrosation. The product of this reaction, N-dansyl-S-nitrosohomocysteine, is a sensitive, direct fluorogenic substrate for the denitrosation activity of protein disulfide isomerase (PDI) with an apparent K(M) of 2 μM. S-nitroso-BSA (BSA-NO) competitiv...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ramachandran, Niroshan, Root, Paul, Jiang, Xing-Mai, Hogg, Phillip J., Mutus, Bulent
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55488/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11493694/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.171180998
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