Mechanism of transfer of NO from extracellular S-nitrosothiols into the cytosol by cell-surface protein disulfide isomerase

N-dansylhomocysteine (DnsHCys) is quenched on S-nitrosation. The product of this reaction, N-dansyl-S-nitrosohomocysteine, is a sensitive, direct fluorogenic substrate for the denitrosation activity of protein disulfide isomerase (PDI) with an apparent K(M) of 2 μM. S-nitroso-BSA (BSA-NO) competitiv...

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Bibliografiske detaljer
Main Authors: Ramachandran, Niroshan, Root, Paul, Jiang, Xing-Mai, Hogg, Phillip J., Mutus, Bulent
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC55488/
https://ncbi.nlm.nih.gov/pubmed/11493694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171180998
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