Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites

Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene diversification suggest participation of AID...

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Publicado no:Sci Rep
Main Authors: Rodríguez-Cortez, Virginia C., Martínez-Redondo, Paloma, Català-Moll, Francesc, Rodríguez-Ubreva, Javier, Garcia-Gomez, Antonio, Poorani-Subramani, Ganesh, Ciudad, Laura, Hernando, Henar, Pérez-García, Arantxa, Company, Carlos, Urquiza, José M., Ramiro, Almudena R., Di Noia, Javier M., Vaquero, Alejandro, Ballestar, Esteban
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548798/
https://ncbi.nlm.nih.gov/pubmed/28790320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07380-9
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