A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence

Infection of mice with strains of Plasmodium yoelii parasites can result in different pathology, but molecular mechanisms to explain this variation are unclear. Here we show that a P. yoelii gene encoding a HECT-like E3 ubiquitin ligase (Pyheul) influences parasitemia and host mortality. We genetica...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Nair, Sethu C., Xu, Ruixue, Pattaradilokrat, Sittiporn, Wu, Jian, Qi, Yanwei, Zilversmit, Martine, Ganesan, Sundar, Nagarajan, Vijayaraj, Eastman, Richard T., Orandle, Marlene S., Tan, John C., Myers, Timothy G., Liu, Shengfa, Long, Carole A., Li, Jian, Su, Xin-zhuan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548792/
https://ncbi.nlm.nih.gov/pubmed/28790316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00267-3
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