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Unraveling heme detoxification in the malaria parasite by in situ correlative X-ray fluorescence microscopy and soft X-ray tomography

A key drug target for malaria has been the detoxification pathway of the iron-containing molecule heme, which is the toxic byproduct of hemoglobin digestion. The cornerstone of heme detoxification is its sequestration into hemozoin crystals, but how this occurs remains uncertain. We report new resul...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Kapishnikov, Sergey, Grolimund, Daniel, Schneider, Gerd, Pereiro, Eva, McNally, James G., Als-Nielsen, Jens, Leiserowitz, Leslie
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548722/
https://ncbi.nlm.nih.gov/pubmed/28790371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06650-w
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