HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

Polymorphisms in the human leukocyte antigen (HLA) class I genes can cause the rejection of pluripotent stem cell (PSC)-derived products in allogeneic recipients. Disruption of the Beta-2 Microglobulin (B2M) gene eliminates surface expression of all class I molecules, but leaves the cells vulnerable...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Gornalusse, Germán G., Hirata, Roli K., Funk, Sarah, Riolobos, Laura, Lopes, Vanda S., Manske, Gabriel, Prunkard, Donna, Colunga, Aric G., Hanafi, Laïla-Aïcha, Clegg, Dennis O., Turtle, Cameron, Russell, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548598/
https://ncbi.nlm.nih.gov/pubmed/28504668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3860
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