Molecular MR Imaging of Myeloperoxidase Distinguishes Steatosis from Steatohepatitis in Nonalcoholic Fatty Liver Disease

PURPOSE: To test whether MPO-Gd, an activatable molecular magnetic resonance (MR) imaging agent specific for myeloperoxidase (MPO) activity, could detect MPO activity in nonalcoholic steatohepatitis (NASH) mouse models and human liver biopsy samples. MATERIALS AND METHODS: In this study, 20 leptin r...

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Publicat a:Radiology
Autors principals: Pulli, Benjamin, Wojtkiewicz, Gregory, Iwamoto, Yoshiko, Ali, Muhammad, Zeller, Matthias W., Bure, Lionel, Wang, Cuihua, Choi, Yuri, Masia, Ricard, Guimaraes, Alex R., Corey, Kathleen E., Chen, John W.
Format: Artigo
Idioma:Inglês
Publicat: Radiological Society of North America 2017
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548451/
https://ncbi.nlm.nih.gov/pubmed/28358240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1148/radiol.2017160588
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