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Independent and Stochastic Action of DNA Polymerases in the Replisome
It has been assumed that DNA synthesis by the leading- and lagging-strand polymerases in the replisome must be coordinated to avoid the formation of significant gaps in the nascent strands. Using real-time single-molecule analysis, we establish that leading- and lagging-strand DNA polymerases functi...
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| Veröffentlicht in: | Cell |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5548433/ https://ncbi.nlm.nih.gov/pubmed/28622507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.05.041 |
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