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Sparse PCA Corrects for Cell-Type Heterogeneity in Epigenome-Wide Association Studies
In epigenome-wide association studies (EWAS), different methylation profiles of distinct cell-types may lead to false discoveries. We introduce ReFACTor, a method based on principal component analysis (PCA) for the correction of cell-type heterogeneity in EWAS. ReFACTor does not require knowledge of...
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| Publicado no: | Nat Methods |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5548182/ https://ncbi.nlm.nih.gov/pubmed/27018579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3809 |
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