Sparse PCA Corrects for Cell-Type Heterogeneity in Epigenome-Wide Association Studies

In epigenome-wide association studies (EWAS), different methylation profiles of distinct cell-types may lead to false discoveries. We introduce ReFACTor, a method based on principal component analysis (PCA) for the correction of cell-type heterogeneity in EWAS. ReFACTor does not require knowledge of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Methods
Prif Awduron: Rahmani, Elior, Zaitlen, Noah, Baran, Yael, Eng, Celeste, Hu, Donglei, Galanter, Joshua, Oh, Sam, Burchard, Esteban G., Eskin, Eleazar, Zou, James, Halperin, Eran
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548182/
https://ncbi.nlm.nih.gov/pubmed/27018579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3809
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