Retrograde synaptic inhibition is mediated by α-Neurexin binding to the α2δ subunits of N-type calcium channels

The synaptic adhesion molecules Neurexin and Neuroligin alter the development and function of synapses and are linked to autism in humans. In C. elegans, post-synaptic Neurexin (NRX-1) and pre-synaptic Neuroligin (NLG-1) mediate a retrograde synaptic signal that inhibits acetylcholine (ACh) release...

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Publicado no:Neuron
Main Authors: Tong, Xia-Jing, López-Soto, Eduardo Javier, Li, Lei, Liu, Haowen, Nedelcu, Daniel, Lipscombe, Diane, Hu, Zhitao, Kaplan, Joshua M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548138/
https://ncbi.nlm.nih.gov/pubmed/28669545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.06.018
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