Interchain hydrogen-bonding interactions may facilitate translocation of K(+) ions across the potassium channel selectivity filter, as suggested by synthetic modeling chemistry

A 4-fold symmetric arrangement of TVGYG polypeptides forms the selectivity filter of the K(+) channel from Streptomyces lividans (KcsA). We report the synthesis and properties of synthetic models for the filter, p-tert-butyl-calix[4]arene-(OCH(2)CO-XOBz)(4) (X = V, VG, VGY), 1–3. The first cation (N...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Mareque Rivas, Juan C., Schwalbe, Harald, Lippard, Stephen J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Physical Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55477/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11504936/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.161257798
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