Interchain hydrogen-bonding interactions may facilitate translocation of K(+) ions across the potassium channel selectivity filter, as suggested by synthetic modeling chemistry
A 4-fold symmetric arrangement of TVGYG polypeptides forms the selectivity filter of the K(+) channel from Streptomyces lividans (KcsA). We report the synthesis and properties of synthetic models for the filter, p-tert-butyl-calix[4]arene-(OCH(2)CO-XOBz)(4) (X = V, VG, VGY), 1–3. The first cation (N...
שמור ב:
| הוצא לאור ב: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2001
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55477/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11504936/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.161257798 |
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